The purpose of this study is to examine what are the effects of the Cervi Cornu on the aged ovariectomized rat model of postmenopausal osteoporosis.
Experimantal groups(UP, MP) were administered water extract of upper portion(ash weight<25%) and middle portion(25%The results of the experiment are as follows,
1. Body weight in upper portion and middle portion of Cervi Cornu group were increased in comparison with control group, but showed no efficiency.
2. The level of serum osteocalcine in upper portion of Cervi Cornu group was increased in comparison with control group, but showed no efficiency. The level of serum calcium, ALP, phosphorus, S-GOT and S-GOT in upper portion and middle portion of Cervi Cornu group showed no significant change.
3. Urinary volume in upper portion and middle portion of Cervi Cornu group showed a significant increase. The level of urine creatinine in upper portion and middle portion of Cervi Cornu group showed a significant decrease. The level of urine calcium to creatinine ratio in upper portion of Cervi Cornu showed a significant increase.
4. The weight of herat, liver, spleen and kidney in upper portion and middle portion of Cervi Cornu group showed no significant change. The weight of uterus in upper portion of Cervi Cornu group was increased in comparion with control group, but showed no efficiency.
5. The weight of tibia ash and the femur length in upper portion and middle portion of Cervi Cornu group showed a significant increase.
According to the above results. effects of the Cervi Cornu on the aged ovariectomized rat model showed a efficiency in elevation of bone density by increasing bone mass and in prevention of renal function failure by ovariectomy. So Cervi Cornu can be used for prevention and curing of postmenopausal osteoporosis.
As for it´s effects, continuous clinical study is needed.
|